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6 Redox-endocrine triad: mechanistic intersections of vitamin D, MI, and melatonin 6.1 Shared molecular targets: OS reduction, mitochondrial stabilization, and anti-inflammatory signaling The integral pathophysiology of PCOS is linked to chronic OS, mitochondrial dysfunction, and subclinical inflammation, all of which fuel endocrine and metabolic disturbances (58)

Most of the carbons from amino acid degradation are converted to pyruvate, intermediates of the TCA cycle or acetyl CoA

Eur J Endocrinol (2014) 170:R213227

We observed an increase in activated MNPs in UC compared to controls before VDZ treatment, with a decrease in responders and an increase in non-responders post-treatment (Fig