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StatPearls [Internet], 2023 June Takaaki Sugihara, Masahiko Koda, Toshiaki Okamoto, Kenichi Miyoshi, Tomomitsu Matono, Kenji Oyama, Keiko Hosho, Jun-ichi Okano, Hajime Isomoto, Yoshikazu Murawaki

One user with 15-year patellar tendonitis reported dramatic initial improvement in the first two weeks, but then the progress drastically slowed despite experimenting with different doses and injection sites

The approval is backed by data from the Phase III SPOTLIGHT and GLOW studies, both of which met the primary endpoint of progression-free survival and key secondary endpoint of overall survival

Levels are also reduced in chronic kidney disease, making klotho a biomarker of renal function as well as aging