Methylglyoxal is a major cell-permeant precursor of advanced glycation end-products (AGEs), which are associated with several pathologies including diabetes, aging and neurodegenerative diseases
During fungal infections, mitochondrial fragmentation (fission) is frequently observed, often preceding apoptotic or pyroptotic cell death ( Candida albicans infection activates DRP1, promoting mitochondrial fission and loss of mitochondrial membrane potential in epithelial cells ( In contrast, fusion events mediated by MFN1/2 can maintain mitochondrial integrity under moderate stress
The inclusion of niacinamide and adenosine harmoniously complements this process, visually smoothing fine lines and providing a firmer feel to the complexion
The variable weight value (VIP) in Orthogonal Partial Least Squares-Discriminant Analysis is a measure of the expression pattern of each metabolite, the explanatory ability and depth of influence on the categorical discrimination of samples in each group, to explore meaningful differential metabolites, and then use the T-test to verify whether the differential metabolites between groups are significant