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Our preclinical findings suggest that vitamin therapy could be a first-line therapy, particularly in patients with low serum B12 and folate levels and elevated serum homocysteine levels. The study provided excellent data in an area of research where there is limited information

Animal studies similarly did not show insulin sensitivity changes

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On the practical question, the evidence points one way: combine at the point of use if at all one syringe or two, given close together and keep them as separate vials in storage, where there is no stability data to justify a pre-mixed blend