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Research suggests this is because stress triggers changes in the central dopamine system, which could theoretically contribute to the disease (Dugger and Dickson 2017

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In December 2024 , the FDA determined that AOD-9604 (both free base and acetate forms) should not be included on the 503A Bulks List for pharmaceutical compounding, citing concerns over limited long-term safety data, peptide impurities, and potential immunogenicity