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NICE guidance (NG49) emphasises a multifaceted approach targeting weight reduction, dietary improvement, and increased physical activity

"This discovery sheds new light on mitochondria and positions them as active regulators of metabolism." Changhan David Lee, Assistant Professor of Gerontology, USC Leonard Davis School The Exercise Connection Human studies show that circulating endogenous MOTS-c levels increase approximately 1.6-fold during exercise and remain elevated about 1.5-fold post-exercise before returning to baseline after roughly four hours

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Studies have shown that dietary supplementation can improve glutathione production, reduce oxidative stress, and improve insulin sensitivity