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Moreover, with relative indifference to subacute decreases of estrogen, the gut dysbiosis stands as a major component in the persistence of bone homeostasis disruption in older PMW, even after the menstrual cycle changes

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Recently, cuproptosis in acute myeloid leukemia was shown to be initiated by inhibiting heme biosynthesis [53] , therefore it is conceivable that iron chelation limited heme to induce cuproptosis in the clinical trials of deferiprone