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Critically, cagrilintide doesn't activate GLP-1 receptors, meaning it doesn't enhance insulin secretion directly or affect incretin hormone pathways

He took the concept one step further: Instead of locating cytoprotection primarily in the stomach, or in the GI tract, he theorized that the peptide could preserve blood vessels and thus protect tissue across every organ of the body

1988, New York: Raven Press, 2: 401-417