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Due to limitations in collecting human patient samples, very few genome-wide association studies (GWAS) in humans have been completed (Urban and Fairbank, 2020)

52,53 Enzymes such as protein kinase C (PKC), MAPK, and protein kinase A (PKA) modulate NOX activation, whereas the tumor suppressor p53 regulates both antioxidant and prooxidant responses, promoting ROS production and apoptosis in cancer cells