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Using transcriptomics, histopathological and western blot analyses, the liver fibrosis markers previously found after 24 weeks on this diet include a significant upregulation of pathways/genes related to fibrogenesis and ECM remodelling ( Col1a1 , Col1a2 , Col3a1 , Col4a1 , Col4a2 , Timp1 and Serpine1 ), TGF ( Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 and Tgfbr2 ) and SMAD signalling (SMAD2 Ser 465/467 phosphorylation), as well as perisinusoidal and portal fibrosis 12,32,33,34

doi: 10.1016/j.ejphar.2014.11.010 159 MaggiCAMeliA

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