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When oxidative stress occurs, it damages neurons, disrupts signaling, and contributes to the progression of neurodegenerative disorders such as: Alzheimers disease Parkinsons disease Multiple sclerosis (MS) Amyotrophic lateral sclerosis (ALS) Over time, excessive oxidative damage impairs mitochondrial function the energy center of brain cells and accelerates neuronal decline

Instead, this phenotype was associated with anxiety/depression (OR 13.878) and hypnotic use (OR 19.956)the latter addressed in the following section

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In Ms4a15 OE cells stimulated with bradykinin, however, the Ca 2+ response was strikingly reduced (Fig