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Thus, understanding these mechanisms is crucial for enhancing the delivery of PLGA nanoparticles across the BBB to minimize systemic toxicity Pharmacological drugs loaded PLGA nanoparticles for PD treatment Several studies demonstrated the effectiveness of PLGA nanosystem in encapsulating pharmacological treatments, thereby improving bioavailability, enhancing BBB penetration, and providing sustained drug release

2.2.3 The effects of ROS on synovial cells In OA, synovial cells play a critical role in both the production of ROS and the amplification of inflammatory responses (Mathiessen and Conaghan, 2017)

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