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The similar affinity (K D ) of p28 for p53 and p63 and longer k off, immediately suggested that p28 could exert its antiproliferative activity by directly binding to p53 and inhibiting its ubiquitination by Cop1

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Notably, Trichodina sp., a prevalent parasite residing in the gills and skin of fish, represents the largest cluster among fish parasites and plays a pivotal role in fish pathology