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Using this DT, a potential scenario distinguishing regeneration of a characteristic cell death pattern after acute hepatotoxic insult and repeated hepatotoxic exposure leading to formation of septal fibrotic walls is proposed based on the spatial pattern of CYP2E1 (key metabolic enzyme) expressing cells

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Our analysis identified multiple metabolic pathways that were altered in both 3xTg CR-fed and DL-fed females, including downregulation of pathways involving the metabolism of amino acids including Cysteine and methionine metabolism, Glycine, serine and threonine metabolism, and Pentose phosphate pathway (Fig