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In a double-blind randomized placebo-controlled study, a combination of acetaminophen (500 mg), acetylsalicylic acid (500 mg), and caffeine (130 mg) (AAC) was compared with ibuprofen (400 mg) and placebo for acute treatment of migraine

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In contrast, patients treated with prolotherapy exhibited only moderate reductions in pain intensity, with statistically significant improvements in VAS scores for LBP and leg pain observed at T3 and T4

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