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However, in specific cases such as when cobalamin(Cbl) deficiency is caused by a lack of transcobalamin II (TCII) or of receptors to TCII-Cbl, OHCbl may not be the preferred form of treatment and CnCbl with its frequent dosages should be superior

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Autologous hematopoietic stem cell transplantation (aHSCT) has been used since the 1990s to treat resistant relapse [34]