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A first-in-human phase 0 clinical study of RNA interferencebased spherical nucleic acids in patients with recurrent glioblastoma

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Patients with insulin-treated diabetes, a history of acute or chronic pancreatitis, gastric or other major bleeding, thyroid neoplasia, hypothyroidism, or hyperthyroidism were excluded, as were patients who had previously experienced side effects from GLP-1 analogs or who had received another investigational product in the past 28 days

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