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Bifidobacteria modulate cognitive processes in an anxious mouse strain

These plant-based options align with the body's natural functions rather than forcing dramatic interventions

Importantly, along with other clock proteins, REV-ERB is subject to ubiquitin-dependent degradation by E3 ubiquitin ligases such as FBXW7 and UBE3A (Zhao et al., 2016), as discussed in more detail in Section 4 E3 ligases and deubiquitinating enzymes in circadian regulation. 2.3 Turnover of core clock proteins The timed degradation of core clock proteins by the ubiquitin-proteasome system ensures proper cycling between repression and activation within the feedback loop, maintaining clock period length

PLoS ONE 9:e112330