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These studies, which adjust for time-changing confounders such as diet, physical activity, and alcohol intake, demonstrate a clear link between active smoking and incident MASLD [58, 59]

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10.1042/CS20160897 132 Gomez Del ArcoP.Martnez-MartnezS.CalvoV.ArmesillaA

217 Throughout the progression from precancerous lesions to localized tumors and from tumors in situ to metastatic tumors, the metabolic preferences of tumor cells continuously change in response to cellular states and environmental conditions, which are regulated by endogenous signals from tumor cells and signals from the tumor microenvironment