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Synucleinopathies Synucleinopathies, including PD, are characterized by the accumulation of fibrillized -synuclein (-syn) in neural tissues (Praschberger et al., 2023), particularly in presynaptic terminals

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In addition, bacterial infection, tissue hypoxia, and other pathological processes, drugs, ionizing radiation, and other exogenous factors can also lead to a large number of intracellular ROS ( Keap1-dependent Nrf2 Regulation Keap1 was an efficient sensor for redox reaction containing broad complex-tramtrack-bric-a-brac (BTB) domain, intermediate region (IVR), double glycine repeat (DGR), and carboxyl terminal region (CTR)

Overall, these findings suggest that caffeine and paraxanthine hold therapeutic potential for improving cognitive function, particularly in younger individuals, by enhancing neuromodulation and reducing -amyloid accumulation