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Like other type I proteins that traverse the lipid bilayer, the lipid-spanning portion of the peptide would be predicted to adopt an alpha-helical secondary conformation, a secondary structure characterized by every amino acid interacting with the 4th amino acid beyond, the so-called i + 4 rule of alpha-helical protein conformations

These usually settle as your body adjusts

Paul Conti, M.D., who trained at Stanford School of Medicine and completed his residency at Harvard Medical School before founding his clinical practice, the Pacific Premiere Group

Purification and characterization of a novel brain-specific 14-kDa protein