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When ketones cover most of the brains energy demands, the remaining glucose can be more efficiently utilized for other purposes, such as the synthesis of alanine and glutamate, glycogenesis, and antioxidant protection [20]

Global, regional, and national burden of Parkinsons disease, 1990-2016

However, it also raises the question why then is hyperhomocysteinemia commonly seen to occur with vitamin B 12 deficiency

With breakthroughs in the field of immunometabolism, the latest research landscape reveals a more hidden yet critical mechanism: the functional polarization of AMs is profoundly driven by intracellular metabolic reprogramming and epigenetic mechanisms, and exosomes are the key vectors translating this intracellular metabolic state into intercellular communication signals (69)