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If these immune checkpoint receptors become upregulated, proliferating T cells can become unresponsive to stimulation, entering a state called T cell exhaustion, eventually succumbing to apoptosis (Figure 2) [83,84,85], in which checkpoint ligands like PD-1 interacts with PD-L1 expressed by human granulomas [86] leads to reduced T cell cytotoxicity, proliferation, and activation [87]

Elevated 8-OHdG levels correlate with aging, cancer, diabetes, and neurodegenerative diseases, making it a critical tool for assessing oxidative DNA damage in clinical and experimental research ( Electron Paramagnetic Resonance Spectroscopy (EPR): It is a powerful tool to directly detect and quantify ROS in biological tissues

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PMC 1287919