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Results Integrated single-cell and single-nucleus transcriptomic datasets from mouse demyelination models and MS patient samples To compare the effects of LPC- and CPZ-induced demyelination on different WM cells, we performed snRNA-seq of the adult mouse corpus callosum, and integrated our data with two additional published scRNA-seq studies of the corpus callosum following LPC- or CPZ-induced demyelination 8,9

It can be divided into four different subfamilies: caspase recruitment domain (CARD), death domain (DD), death effector domain (DED), and the pyrin domain (PYD) 40