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Levels JH, Marquart JA, Abraham PR, et al

This has led to the concept of pathway-specific hepatic insulin resistance, where the insulin activation pathway involving protein kinase B/forkhead box protein O1 is inhibited, while the SREBP-1c pathway remains activated (61)

Currently, lactate fulfills three key roles: it acts as the primary energy source, serves as a significant precursor for gluconeogenesis, and functions as signaling molecules with autocrine, paracrine, and endocrine-like actions, collectively referred to as lactormone [41]

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