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Such that, the secretion of inflammatory cytokines, such as tumor necrosis factor- (TNF), would lead to neuroinflammation and migraine episodes by increasing the cellular permeability and interactions (11, 12)

Autonomic dysfunction including bladder, bowel and sexual dysfunction, and cardiovascular dysautonomia, usually precedes motor symptoms, but become more relevant with disease progression 160

Interestingly, this infection has also been connected to ankylosing spondylitis, an autoimmune condition that causes pain and fatigue

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