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Frontiers Resisting decline: the neuroprotective role of resistance exercise in supporting cerebrovascular function and brain health in aging Frontiers Recent advances in crocodilian oil research: bioactive components and potential therapeutic applications Ioning out glioblastoma: ferroptosis mechanisms and therapeutic frontiers Cell Death Discovery Rethinking the role of synergy calculations in the next century of drug combination discovery ScienceDirect

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Generally, mitochondria are the foremost generator of cellular energy in human cells by converting oxygen and nutritional elements to adenosine triphosphate (ATP) via oxidative phosphorylation pathway

Conclusion Our study demonstrates that A45, but not PEG, induces distinct metabolomic reprogramming in pathways related to amino acid, energy, and redox metabolism, which are consistent with the transition from acute inflammation to fibrosis