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A widely used dynamic in-vitro system in food and pharmaceutical research to analyze how nutrients and medicinal ingredients are released and absorbed is TIM [24, 116]

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Abbreviations CBS cystathionine -synthase CSE cystathionine -lyase DC dendritic cell Hcy homocysteine HHcy hyperhomocysteinaemia MMP matrix metalloproteinase MTX methotrexate NAC N-acetyl cysteine NET neutrophil extracellular trap NF-B nuclear factor B NO nitric oxide OS Oxidative stress PASI psoriasis area and severity index PsA psoriatic arthritis RA rheumatoid arthritis ROS reactive oxygen species SAH S-adenosyl-L-homocysteine SAM S-adenosyl-L-methionine SFN Sulforaphane Treg regulatory T cell VEGF vascular endothelial growth factor Author Contribution Xiran Lin designed and wrote the manuscript

Waseem, Muhammad, Divya Kumari, and Talya Toledano