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[104] You are encouraged to report negative side effects of prescription drugs to the FDA

10.1172/JCI158788 7

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Abbreviations ON: Optic neuritis NSAIDs: Nonsteroidal anti-inflammatory drugs NPs: Nanoparticles AuNPs: Gold nanoparticles OCT: Optical coherence tomography DEX: Dexamethasone-sodium phosphate HA: Hyaluronic acid LBPS: Lycium barbarum polysaccharides HCFs: Human corneal fibroblasts AMD: Age-related macular degeneration APS: Astragalus polysaccharides ARPE-19: Human retinal pigment epithelial cells ER: Endoplasmic reticulum DR: Diabetic retinopathy PGBL: Ginkgo biloba leaf-derived polysaccharides TNF-: Tumor necrosis factor- DCPS: Dendrobium candidum polysaccharides HCEC: Human corneal epithelial cells SA: Sodium alginate AOS: Alginate oligosaccharides HCS: High molecular weight chitosan SLNs: Solid lipid nanoparticles NLCs: Nanostructured lipid carriers LDCs: Lipid-drug conjugates PLGA: Polylactic-co-glycolic acid PGA: Polyglycolic acid PEG: Polyethylene glycol RES: Reticuloendothelial system ASIV-LNCs: Astragaloside-IV loaded into lipid nanocapsules PAMAM: Polyamidoamine PLL: Poly(L-lysine) PEI: Polyethylenimine PPI: Poly (propylene imine) OIR: Oxygen-induced retinopathy TA: Triamcinolone acetonide D-TA: Dendrimer-conjugated TA SPIONs: Superparamagnetic iron oxide nanoparticles PVA: Polyvinyl alcohol MSCs: Mesenchymal stem cells DCIONs: Dextran-coated iron oxide nanoparticles TGF-: Tumor growth factor- CsA: Cyclosporine A OSI: Ocular surface inflammation Th17: T helper cell 17 CMVR: Cytomegalovirus retinitis MBL: Mannose-binding lectin FFA: Fluorescein fundus angiography VEGF: Anti-vascular endothelial growth factor PDR: Proliferative diabetic retinopathy RPE: Retinal pigment epithelium MS-ON: Multiple sclerosis-related optic neuritis NMO-ON: Neuromyelitis optica-related optic neuritis AQP4-IgG: Antibodies against astrocyte water channel protein 4 SLE: Systemic lupus erythematosus GMs: Graphene materials EFMs: Electrospun fibrous membranes ROS: Reactive oxygen species SOD: Superoxide dismutase CNTs: Carbon nanotubes FET: Field-effect transistor PCL-PEG-PCL: Polycaprolactone-polyethylene glycol-polycaprolactone DFAB: Difluprednate ACs: Anterior chamber cells VRC: Voriconazole VE: Vitamin E PVP: Poly(vinylpyrrolidone) PCL: Poly(-caprolactone) OFX: Ofloxacin COX: Cyclooxygenase CS: Chitosan HET-CAM: Hens egg test-chorioallantoic membrane FB: Flurbiprofen SA: Sodium arachidonate HENC: Human corneal endothelial cells HCC: Human cornea construct LX: Lornoxicam PBA: Phenylboronic acid INS: In-situ nanosuspension MS: Micellar solution MNFs: Nanomicellar formulations Oc-40: Octoxynol-40 NFAT: Nuclear factor of activated T cells CD4: Differentiation cluster 4 CD8: Differentiation cluster 8 TAC: Tacrolimus TGNPs: Tacrolimus gellan gum nanoparticles MSNAPTES: 3-aminopropyltriethoxysilane ERG: Electroretinography AKC: Atopic keratoconjunctivitis VKC: Vernal keratoconjunctivitis NCs: Nano-capsules EAU: Experimental autoimmune uveitis KO: Knockout EDE: Experimental dry eye Myr: Myricetin CUR: Curcumin OA: Oleanolic acid UA: Ursolic acid PLA2: Phospholipase A2 SM: Standard mixture SAS: SA solution SDF-1: Stromal-derived factor-1 THY: Thymol DG: Dipotassium glycyrrhizinate ETP: Etoposide TRAM2: Translocation-associated Membrane Protein 2 NPMOF: Nanoscale zirconium-porphyrin metal-organic frameworks MPS: Methylprednisolone PAM: Photoacoustic microscopy PT-OCT: Photothermal OCT CLs: Contact lenses TiO 2 NPs: Titanium dioxide nanoparticles PMMA: Polymethyl methacrylate SPOTS: Semiquantitative preclinical ocular toxicology scoring LECs: Lens epithelial cells BRB: Blood-retinal barrier FA: Fluocinolone acetonide LE: Loteprednol etabonate BCEC: Bovine conjunctival epithelial cell BCoEC: Bovine corneal epithelial cells LPS: Lipopolysaccharide T-HCl: Terbinafine hydrochloride BSF: Besifloxacin hydrochloride PC: Phosphatidylcholine CH: Cholesterol SA: Stearylamine HA-LCS-NPs: Hyaluronic-acid-modified lipid-polymer hybrid nanoparticles MRT: Mean residence time AUC: Area under the curve P app : Apparent permeability coefficients FD-C: Franz diffusion cell PMNLs: Polymorphonuclear leukocyte infiltration NP-NLC-Gel: Hydrogel modified nanostructured lipid carrier RPCECs: Rabbit corneal epithelial cells CH-MEs: Chitosan-coated cationic microemulsions NIPAAM: N-isopropylacrylamide VP: Vinyl pyrrolidone MAA: Methacrylate P40S: Polyoxyl 40 stearate P80: Polysorbate 80 HA CS-NPs: Hyaluronic-acid chitosan-sodium tripolyphosphate nanoparticle Gamma CD: Gamma-cyclodextrin Dex-SA-FFFE: Dexamethasone-peptide conjugate HPMC: Hydroxypropyl methylcellulose HP--CD: Hydroxypropyl--cyclodextrin F6: Phosphatidylcholine, cholesterol, span 60, and stearylamine at a molar ratio of 1:1:1:0.15 PBA-CS-VE: Phenylboronic acid conjugated chitosan oligosaccharide-vitamin E copolymer COL: Chitosan oligosaccharide lactate CTAB: Hexadecyltrimethylammonium bromide CNLC: Cationic nanostructured lipid carriers COS: Chitosan oli gosaccharides mPEG-b-PLGA: Methoxy poly (ethylene glycol)-block-poly (D, L)-lactic-co-glycolic acid PVCL-PVA-PEG: Polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol GA: Gambogic acid Vit E TPGS: Vitamin E tocopherol polyethylene glycol succinate Oc-40: Octoxynol-40 TA: Sodium taurocholate MBA: N, N-methylenebis-acrylamide TG: Triethyleneglycol dimethacrylate MC: Methylcellulose ALG: Alginate References Huerva V, Ascaso FJ, Grzybowski A