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Key pathways such as c-MET and TGF-, modulated by factors like MACC1, are central to this process

697,698 Viral hepatitis Clinical observations Viral hepatitis is a major risk factor for chronic liver disease and HCC, contributing to significant mortality worldwide, with hepatitis B and C accounting for the greatest global burden

In summary, the respiratory epithelium establishes a primary defense barrier through the mucusciliary system and TJs, while coordinating immune responses via PRRs, DAMP signaling, and cytokine networks

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