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For liver-specific genetic deletions, mice were injected via the tail vein with 2.510 11 GC of AAV-TBG-Cre (Addgene, 107787-AAV8) in PBS

10.4161/auto.34398 34

The effect was dose-dependent, with subcutaneous administration at 15 mg/kg showing significant reductions in fasting glucose and HbA1c markers

Small RNA profiling of piRNAs in colorectal cancer identifies consistent overexpression of piR-24000 that correlates clinically with an aggressive disease phenotype