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TB-500 (Thymosin Beta-4) Research Wound Healing Acceleration 4261% Improvement Over Controls (PubMed, 1999) A foundational pre-clinical study published in the Journal of Investigative Dermatology investigated Thymosin Beta-4 in a rat full-thickness wound model

These conclusions about AOM not generating direct toxicity on BBB endothelial cells in vivo are also supported by AOM-treated mice not showing BBB permeability to near coma, as is reported in this study and by others

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The combination of chitin and alginate with the active agent disclosed herein acts as a controlled-release formulation, restricting the diffusion of the active agent from the formulation