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There have been attempts to use only methionine-deficient (MD) or choline deficient (CD) diets to induce NASH (Caballero et al., 2010)

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The cell-free area was quantified using ImageJ by measuring the gap at each time point and normalizing it to the initial free area immediately after insert removal

The speed of orforglipron's clinical development from Phase 1 to regulatory submission, spanning approximately 5 years from first-in-human dosing to FDA submission, represents one of the fastest development timelines in obesity pharmacotherapy history