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Moreover, IL-37 was also demonstrated to be elevated in patients with AS, with its increase associated with disease severity and bone mineral density (61)

Bushen-Yizhi formula ameliorates cognitive dysfunction through SIRT1/ER stress pathway in SAMP8 mice

Nevertheless, ALS is considered a multifactorial disease, due to a combination of risk-genotypes that interact with environmental factors, impacting and accelerating the neurodegenerative cascade ( Although numerous preclinical and clinical trials have been performed, a cure for ALS does not exist yet