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For example, resveratrol (plant-derived phytoalexin) treatment triggers a strong signal for autophagy (p62 accumulation) through JNK activation leading to death in imatinib-resistant chronic myelogenic leukemia cells (CML) [369, 370]

We first confirmed that biallelic SORD mutations result in complete loss of the protein, whereas heterozygous mutations lead to reduced SORD expression