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[15], [16] Epithalon appears to help maintain and improve the normal structure of the eye retina condition while increasing the bioelectric and functional activity of the retina due to the preservation of its morphological structure

It has been shown that modification of the C-3 position can effectively enhance the antiproliferative ability of caudatin against various cancer cell lines compared to the parent compound, presumably due to improved membrane permeability facilitated by increased lipophilicity (Figure 1g) exhibited the highest activity against HepG2 cells (IC 50 3.11 M) ( To summarize, the esterification and glycosylation of C-3 OH might be beneficial for improving bioactivity and lipid solubility

We thank the Biological Services Unit at QUB for supporting the animal studies undertaken

Clin Exp Pharmacol Physiol