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The thiol ester is oxidized by an oxygenase which adds a -hydroxyl-group while the substrate is still attached to the thioesterase domain, and finally, Bht is released from the module (Donadio et al., 2005)

Specifically, hyperosmolarity induced by D-mannitol supplementation induced increases in intracellular Ca 2+ that could be suppressed by 1 mmol/l L-carnitine (Fig