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Antithrombotic properties Recent investigations show that ESC and esculin pentasulfate (EPS), a heavily sulfated esculetin derivative, significantly reduced thrombus weight and length, prolonged APTT, PT, and TT, and confirmed strong systemic anticoagulant activity in rat venous thrombosis models induced by inferior vena cava ligation

Lipids with the following references were purchased from Avanti Polar Lipids: 1-oleoyl-2-(6-((4,4-difluoro-1,3-dimethyl-5-(4-methoxyphenyl)-4-bora-3a,4a-diaza-s-indacene-2-propionyl)amino)hexanoyl)-sn-glycero-3-phosphate (TopFluor-TMR-PA, #810240C), 23-(dipyrrometheneboron difluoride)-24-norcholesterol (TopFluor-Cholesterol, #810255P), 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC, #850457C), L--phosphatidylethanolamine, transphosphatidylated (Egg Trans PE, #841118C) 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(cap biotinyl) (Biotinyl Cap PE, #870273C), 1-palmitoyl-2-(dipyrrometheneboron difluoride)undecanoyl-sn-glycero-3-phosphoethanolamine (TopFluor-PE, #810282C), 1-palmitoyl-2-(dipyrrometheneboron difluoride)undecanoyl-sn-glycero-3-phospho-L-serine (TopFluor-PS, #810283C)

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Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer