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To further strengthen the contribution of OS in ALS, an increase in the level of several proteins oxidatively modified and consequently inactivated has been found in SOD1 G93A transgenic mice and correlated with SOD1 mutation: such proteins are SOD1 itself, translationally controlled tumor protein (TCTP, which normally processes calcium binding activity and acts as a cytoprotective factor), and ubiquitin carboxyl-terminal hydrolase isoenzyme L1 (UCH-L1, which plays an important role in the ubiquitin-proteasome system, UPS)

Early diagnosis and treatment not only relieve symptoms, but also prevent long-term nerve damage or other serious complications

During pregnancy, extra fluid is needed to maintain the amniotic fluid that surrounds, cushions, and protects the developing fetus and to support an increase in maternal blood volume

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