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Study 3: Combination With Diet Independent work showed that NNMT inhibition plus a lean/low-fat diet accelerated weight and fat loss beyond diet alone, improved the lean-mass-to-body-weight ratio, and ameliorated obesity-linked liver pathologies

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These stubborn areas are characterized by several factors including high alpha-2 adrenergic receptor density relative to beta receptors, reduced blood flow, and greater insulin sensitivity leading to efficient fat storage