To meet the diagnostic criteria for cEDS, a person must meet: Major criterion 1 AND major criterion 2 OR Major criterion 1 AND three or more minor criteria Major Criteria Skin hyperextensibility and atrophic scarring Generalized joint hypermobility Minor Criteria Easy bruising Soft, doughy skin Skin fragility (or traumatic splitting) Molluscoid pseudotumors Subcutaneous spheroids Hernia (or history thereof) Epicanthal folds Complications of joint hypermobility (e.g., sprains, dislocations/subluxations, pain, flexible flatfoot) Family history of a first-degree relative who meets clinical criteria Hypermobility Spectrum Disorders (HSD) HSD in Adults Adults are diagnosed with HSD if they have symptomatic joint hypermobility that cannot be explained by other conditions
The endothelial-like tumor cells can secrete collagens IV and VI, proteoglycans, heparan sulfate, laminin and tissue transglutaminase antigen 2, aiding in tubular structure formation and stabilization [67]
These molecules promote the growth of axonal sprouts, physically encouraging damaged nerves to regenerate and reconnect
Excipient quality: All excipients must comply with pharmacopoeia standards to ensure they are free of impurities and microbial contamination
