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Inhibition of the first rate-limiting enzyme of one-carbon metabolism (PHGDH) has been shown to promote cell growth arrest, a phenomenon that occurs as a result of an accumulation of intracellular reactive oxygen species (ROS) following the inhibition of glutamine metabolism

Dem Krper eine ausreichende Menge an Vitaminen zuzufhren gelingt vielen Menschen im Alltag nicht mehr

10.1016/j.neuroscience.2009.01.021 Neuroscience 135 WeiZ.TongguangW.ZhongP.MillerD

System x C blockade targets cancers with mut-p53 accumulation Since cancer cells with mut-p53 accumulation are vulnerable to oxidative stress, we next sought to identify potential antioxidative stress genes which when suppressed, would preferentially kill cancer cells with stabilized mut-p53