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It is likely that the somatostatin actions are dependent on the density and distribution of SST receptor subtypes in different tissues ( Figure 2 Intra-islet actions of somatostatin The human pancreas includes 1-3 million pancreatic islets ( Figure 1 )

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These gaps underscore the urgent need for systematic clinical safety assessments

To further increase the rigor of these assays, we assessed the enrichment capability of the three antibodies by semiquantifying the intensities of three spiked-in modified peptides both before and after enrichment by each antibody (Extended Data Fig