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Characterization of GDF2 mutations and levels of BMP9 and BMP10 in pulmonary arterial hypertension

Vercellini P, Somigliana E, Vigan P, Abbiati A, Daguati R, Crosignani PG

Specifically, copper's ability to enhance MMP expression, particularly MMP-1, which regulates collagen breakdown, might lead to a temporary increase in cellular debris or a transient inflammatory response as the skin purges and rebuilds