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Mattson MP, Chan SL

Available from: 60.Zhang T, Sturgis TF, Youan BBC

The reprogramming of TAMCs correlates with increased expression of CD69, IFN-, granzyme B (GzmB), and Ki67 in T cells, while the expression of PD-1 is reduced

We propose that chronic exposure to a particular suite of environmental and genetic factors elicits a trajectory of impaired mitochondrial biology that maximally impacts subsets of mitotypes abundant in the hippocampus, entorhinal cortex, and cerebral cortex, which eventually surfaces as the hallmark features of AD