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7,8 Furthermore, insulin resistance is also associated with several disabling conditions, including osteoarthritis, muscle loss, frailty, and infertility (Table 2)

In this review, we examine the current state of knowledge surrounding GHSR heterodimers, and how we can apply this knowledge to various pharmacological treatments

Mechanisms of action: NF-B inhibition: KPV inhibits the activation of nuclear factor kappa-B (NF-B), the master regulator of the inflammatory response