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Counters Cholinergic losses from Nucleus Basalis of Meynert (NBM) Injuries: One important pathological loss following head injury results from trauma to the basal midbrain and loss of cholinergic cells located in the NBM and/ or loss of axons providing cholinergic input to the cerebral hemispheres, hippocampus, and other critical brain structures

and (3) Dual-action therapeutics exemplified by Targ-TAP (scFvTarg-tick anticoagulant peptide fusion), demonstrating synergistic antiplatelet/anticoagulant activity that reduces infarct size and preserves cardiac function in vivo [151,152,153]

Together, these results show that exogenous IL-6 may increase ICAM-1 expression in endothelial cells when no bacteria is present, and that 100 ng/mL exogenous IL-6 may decrease ICAM-1 expression in the presence of P

An J, Fisher M, Rettig MB