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Dichloroacetate (DCA), an inhibitor of pyruvate dehydrogenase, can cross the blood-brain barrier, activating P126 and mitochondrial ROS production, restoring normal mitochondrial function in 53 out of 125 gliomas patients [81, 216, 217]

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When the B12-haptocorrin complex reaches the small intestines, haptocorrin releases the B12 where it then attaches to intrinsic factor

Conversely, miR-193a-3p inhibition promoted tumorigenic effect, which could be diminished by S6K2 knock-down, suggesting that miR-193a-3p has a role in tumor suppression in NSCLC through the targeting of S6K2