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Preclinical studies demonstrate improvements in tendon-to-bone healing, with enhanced collagen organization and increased tensile strength in healed tissues

Serum levels of IL-4, IL-6, IL-10, calcitonin gene-related peptide (CGRP), MMP-9, tumor necrosis factor-alpha (TNF), TGF, and malondialdehyde (MDA) as oxidative stress marker were also decreased while the level of IL-2, IFN-, and glutathione (GSH) were increased at the end of study ( The above studies suggest the therapeutic potential of IFN- in SM-induced lung injury by reduction of inflammatory mediators and oxidative stress as well as respiratory symptoms but increased PFT values in SM exposed patients with lung disorders

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