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Results Discovery of a YPEL5-CTLH-dependent bromodomain (BD)-containing protein 4 (BRD4) degrader To identify MGDs that exploit novel E3 ligases, we used a degron display approach whereby we functionalized a known high-affinity ligand for a target protein with a library of chemical tags containing covalent-acting warheads (Supplementary Table 1)

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This highlights the dual pathway by which maternal smoking harms offspring, emphasizing the need to address both direct and birthweight-mediated effects in interventions targeting prenatal health

But I'd bet it's been thousands.'' It's now potentially millions